Welcome to the latest “Allergy, Asthma & Immunology Innovations” episode. This episode is the latest in our series about mast cell diseases. It focuses on mastocytosis, the role of bone marrow in diagnosis, and KIT Inhibitors in clinical trials for treating systemic mastocytosis.
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The podcast series is sponsored by Blueprint Medicines.
The role of bone marrow in mastocytosis
Podcast hosts Kortney Kwong Hing and Payel Gupta, MD are joined by Douglas Tremblay, MD, a hematologist-oncologist at the Icahn School of Medicine at Mount Sinai and principal investigator on numerous initiatives, including clinical trials for KIT inhibitor bezulastinib.
Dr. Tremblay explains the importance of a bone marrow biopsy in diagnosing systemic mastocytosis. He describes the function of bone marrow, what a patient can expect when having a bone marrow biopsy, and what doctors are looking for when evaluating patients for mastocytosis.
Latest research in mastocytosis treatment
Dr. Tremblay discusses the bone marrow’s function and the KIT mutation’s role in mast cell disease. Then he delves into KIT inhibitors, explaining their function, the risks and benefits for patients, and how he performs clinical trials for mastocytosis.
Learn more about the role of bone marrow in systemic mastocytosis and the exciting new developments with KIT inhibitors.
Podcast Timestamps
01:49 – Hematologist’s role in diagnosing and treating mast cell disease
04:51 – Bone marrow biopsy: what is it, and why is it needed for mastocytosis
08:14 – KIT mutation
09:58 – KIT mutation testing (digital droplet PCR)
12:23 – Current research for treating mast cell disease
13:58 – KIT inhibitors: Avapritinib, Bezuclastinib, Elanestinib
17:36 – Indolent mastocytosis versus advanced mastocytosis
18:38 – How the KIT inhibitors work
21:31 – What does ‘NIB’ mean in the medication name?
22:53 – Are KIT inhibitors a cure for mast cell disease?
25:33 – Do KIT inhibitors weaken the immune system?
27:33 – Timeline for the new KIT inhibitors’ FDA approval
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