Latex Allergy and Vaccines
Hard, dry latex is minimally processed and is used to make vial closures for some vaccines. There is concern that latex proteins may be mixed with the medication through packaging and storage of the vaccine vial, and also through puncturing the vial stopper to “draw up” the vaccine.
The same concern exists with vaccines that are stored in syringes with latex in the plungers.
The extent of risk is unknown, however, because information regarding the precise composition of the closure in any particular drug packaging is not always accessible. There are other potential allergens in vaccines such as gelatin and eggs which may contribute to allergic reactions.
Therefore, the reported risk of latex allergic reactions to vaccines appears very small in comparison with the number of vaccines that are administered each year.
COVID-19 Vaccines and Latex Allergy
The Pfizer/BioNTech, Moderna and Johnson & Johnson COVID-19 vaccines include vial stoppers that are not made with natural rubber latex. People with latex allergy are not at risk for a latex allergy reaction from the vaccine. Learn more on our COVID-19 vaccine allergy page.
Precautionary measures for vaccination with a latex allergy
Current practice recommendations (precautionary measures) are based on limited data. Therefore, they should be viewed as compromises rather than solutions.
“Popping the top”
“Popping the top” prevents the puncturing of a latex stopper for safer administration. However, there is still a possibility that latex allergic proteins have contaminated the medicine during the period of storage. Also, other contaminants may enter the medication if the vial is opened.
“One stick rule”
The “one stick rule” assumes that a single stick through the vial seal minimizes latex allergen distribution into the medication, while maintaining a closed system that limits potential for contamination. However, it does not adequately address the possibility that latex allergen can seep into medications during both shipping and storage, as well as during the single puncturing event.
Post vaccination observation
Post-vaccination observation by a qualified medical professional for a period of at least 15 minutes, and up to 2 hours.
Other recommendations for administering vaccines in latex-allergic patients
- Use ampules of medications that do not contain latex when the content is known (most have less than 20% latex content).
- Use a glass syringe. Otherwise, inject immediately after withdrawal.
- Wear latex free gloves when administering vaccinations.
- Avoid applying bandages or plasters if content is unknown.
- Look for the following caution on medical products but be aware that not all latex containing products will be labelled, “Caution: This Product Contains Natural Rubber Latex Which May Cause Allergic Reactions.”
- Do you have spina bifida?
- Have you had several surgeries throughout your life?
- Do you have Allergies to avocados, bananas, kiwis, chestnuts or apples?
- Do your lips swell when you blow up a balloon?
- Do you have a history of rashes, itching, hives, eye irritation, runny nose or asthmatic symptoms (coughing, wheezing or bronchospasms) after handling gloves, balloons, condoms, or other latex items?
- Is your mouth itchy after dental work?
- Do you have frequent contact with natural rubber products either at home or work?
- Have you ever had an anaphylaxis of unknown origin?
Flu Vaccine – Latex Allergy Patient Alert
FLUAD™ Adjuvanted Quadrivalent Influenza Vaccine 0.5ml single-dose prefilled needle-less syringes (pack of 10) poses a risk of latex exposure. Other quadrivalent vaccines do not contain latex, but it is important to always check with your healthcare provider about the potential for latex exposure before receiving any vaccine.
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