How to Treat Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

Check out the latest episode of the Allergy, Asthma & Immunology Innovations podcast. We continue to explore chronic rhinosinusitis with nasal polyps (CRSwNP). In this episode, we review different treatment options for nasal polyps and why they may return even after surgery.

Co-hosts, Payel Gupta, MD, and Kortney are joined by Maeve O’Connor, MD, a board-certified allergist and immunologist. Together, they walk through the full treatment journey for people with CRSwNP, from daily nasal care all the way to surgery and biologic medications.

This episode was released around World Anosmia Day on Feb. 27 because loss of smell is one of the biggest symptoms that affects the daily life of people with CRSwNP.

Check out the podcast on ItchPodcast.com or download it for listening anytime, anywhere!

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This podcast is for informational purposes only and does not substitute professional medical advice. Any mention of brands is also informational and not an endorsement. Always consult with your healthcare provider for any medical questions or concerns.

We thank Sanofi-Regeneron for sponsoring this podcast episode.

Key Takeaways from our Episode on Nasal Polyps Treatment

CRSwNP is a long-term condition caused by inflammation (swelling) inside the nose and sinuses. Because the inflammation does not go away on its own, treatment focuses on managing it over time rather than curing it.

  • Nasal polyps can come back. Even after surgery or treatment, polyps can return because the inflammation that causes them is still active in the body.
  • Treatment starts with daily nasal care. Saline rinses and nasal steroid sprays are the foundation of treatment and need to be used regularly, not just when symptoms flare.
  • Surgery helps, but it is not a cure. Sinus surgery can remove polyps and help nasal sprays work better, but ongoing treatment is still needed afterward.
  • Biologic medications target the root cause. There are four biologic medications approved for CRSwNP. They work by calming the inflammation that keeps polyps coming back.
  • Shared decision-making helps you choose the right treatment. Your allergist or ENT can help you weigh your options and set realistic long-term goals.

Podcast Timestamps from our Episode about CRSwNP Treatment

01:44 — What is World Anosmia Day?

03:02 — Why nasal polyps keep coming back

04:50 — Daily nasal care

06:20 — When to consider surgery

09:26 — Add-on treatments

11:46 — What is AERD?

16:05 — What is debulking?

18:20 — How biologics work

24:46 — Why we avoid oral corticosteroids

27:11 — Choosing the right treatment

30:46 — Why follow-up visits matter

More Resources about CRSwNP and Nasal Polyps

Previous CRSwNP Podcasts